No Impairment in Host Defense against Streptococcus pneumoniae in Obese CPEfat/fat Mice
Identifieur interne : 000E24 ( Main/Exploration ); précédent : 000E23; suivant : 000E25No Impairment in Host Defense against Streptococcus pneumoniae in Obese CPEfat/fat Mice
Auteurs : Peter Mancuso [États-Unis] ; Edmund O Rien [États-Unis] ; Joseph Prano [États-Unis] ; Deepti Goel [États-Unis] ; David M. Aronoff [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Obésité.
- microbiologie : Obésité.
- métabolisme : Carboxypeptidases, Obésité.
- physiologie : Streptococcus pneumoniae.
- Animaux, Femelle, Humains, Immunité innée, Poids du corps, Souris, Souris obèse.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Carboxypeptidases.
- immunology : Obesity.
- metabolism : Obesity.
- microbiology : Obesity.
- physiology : Streptococcus pneumoniae.
- Animals, Body Weight, Female, Humans, Immunity, Innate, Mice, Mice, Obese.
Abstract
In the US and globally, dramatic increases in the prevalence of adult and childhood obesity have been reported during the last 30 years. In addition to cardiovascular disease, type II diabetes, and liver disease, obesity has recently been recognized as an important risk factor for influenza pneumonia. During the influenza pandemic of 2009, obese individuals experienced a greater severity of illness from the H1N1 virus. In addition, obese mice have also been shown to exhibit increased lethality and aberrant pulmonary inflammatory responses following influenza infection. In contrast to influenza, the impact of obesity on bacterial pneumonia in human patients is controversial. In this report, we compared the responses of lean WT and obese CPE
Url:
DOI: 10.1371/journal.pone.0106420
PubMed: 25203099
PubMed Central: 4159279
Affiliations:
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last="Prano">Joseph Prano</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Goel, Deepti" sort="Goel, Deepti" uniqKey="Goel D" first="Deepti" last="Goel">Deepti Goel</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Aronoff, David M" sort="Aronoff, David M" uniqKey="Aronoff D" first="David M." last="Aronoff">David M. Aronoff</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Division of Infectious Diseases, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Vanderbilt University, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Carboxypeptidases (metabolism)</term><term>Female</term><term>Humans</term><term>Immunity, Innate</term><term>Mice</term><term>Mice, Obese</term><term>Obesity (immunology)</term><term>Obesity (metabolism)</term><term>Obesity (microbiology)</term><term>Streptococcus pneumoniae (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Carboxypeptidases (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Immunité innée</term><term>Obésité (immunologie)</term><term>Obésité (microbiologie)</term><term>Obésité (métabolisme)</term><term>Poids du corps</term><term>Souris</term><term>Souris obèse</term><term>Streptococcus pneumoniae (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carboxypeptidases</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carboxypeptidases</term><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Streptococcus pneumoniae</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Streptococcus pneumoniae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Female</term><term>Humans</term><term>Immunity, Innate</term><term>Mice</term><term>Mice, Obese</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Immunité innée</term><term>Poids du corps</term><term>Souris</term><term>Souris obèse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the US and globally, dramatic increases in the prevalence of adult and childhood obesity have been reported during the last 30 years. In addition to cardiovascular disease, type II diabetes, and liver disease, obesity has recently been recognized as an important risk factor for influenza pneumonia. During the influenza pandemic of 2009, obese individuals experienced a greater severity of illness from the H1N1 virus. In addition, obese mice have also been shown to exhibit increased lethality and aberrant pulmonary inflammatory responses following influenza infection. In contrast to influenza, the impact of obesity on bacterial pneumonia in human patients is controversial. In this report, we compared the responses of lean WT and obese CPE<italic><sup>fat/fat</sup></italic> mice following an intratracheal infection with <italic>Streptococcus pneumoniae</italic>, the leading cause of community-acquired pneumonia. At 16 weeks of age, CPE<italic><sup>fat/fat</sup></italic> mice develop severe obesity, hyperglycemia, elevated serum triglycerides and leptin, and increased blood neutrophil counts. There were no differences between lean WT and obese CPE<italic><sup>fat/fat</sup></italic> mice in survival or lung and spleen bacterial burdens following intratracheal infection with <italic>S. pneumoniae</italic>. Besides a modest increase in TNF-α levels and increased peripheral blood neutrophil counts in CPE<italic><sup>fat/fat</sup></italic> mice, there were not differences in lung or serum cytokines after infection. These results suggest that obesity, accompanied by hyperglycemia and modestly elevated triglycerides, at least in the case of CPE<italic><sup>fat/fat</sup></italic> mice, does not impair innate immunity against pneumococcal pneumonia.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cecere, Lm" uniqKey="Cecere L">LM Cecere</name></author><author><name sortKey="Littman, Aj" uniqKey="Littman A">AJ Littman</name></author><author><name sortKey="Slatore, Cg" uniqKey="Slatore C">CG Slatore</name></author><author><name sortKey="Udris, Em" uniqKey="Udris E">EM Udris</name></author><author><name sortKey="Bryson, Cl" uniqKey="Bryson C">CL Bryson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gidding, Ss" uniqKey="Gidding S">SS Gidding</name></author><author><name sortKey="Nehgme, R" uniqKey="Nehgme R">R Nehgme</name></author><author><name sortKey="Heise, C" uniqKey="Heise C">C 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J">JB Freeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hodgson, Ka" uniqKey="Hodgson K">KA Hodgson</name></author><author><name sortKey="Govan, Bl" uniqKey="Govan B">BL Govan</name></author><author><name sortKey="Walduck, Ak" uniqKey="Walduck A">AK Walduck</name></author><author><name sortKey="Ketheesan, N" uniqKey="Ketheesan N">N Ketheesan</name></author><author><name sortKey="Morris, Jl" uniqKey="Morris J">JL Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faggioni, R" uniqKey="Faggioni R">R Faggioni</name></author><author><name sortKey="Jones Carson, J" uniqKey="Jones Carson J">J Jones-Carson</name></author><author><name sortKey="Reed, Da" uniqKey="Reed D">DA Reed</name></author><author><name sortKey="Dinarello, Ca" uniqKey="Dinarello C">CA Dinarello</name></author><author><name sortKey="Feingold, Kr" uniqKey="Feingold K">KR Feingold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tilg, H" uniqKey="Tilg H">H Tilg</name></author><author><name sortKey="Moschen, Ar" uniqKey="Moschen A">AR Moschen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Mancuso, Peter" sort="Mancuso, Peter" uniqKey="Mancuso P" first="Peter" last="Mancuso">Peter Mancuso</name></region><name sortKey="Aronoff, David M" sort="Aronoff, David M" uniqKey="Aronoff D" first="David M." last="Aronoff">David M. Aronoff</name><name sortKey="Goel, Deepti" sort="Goel, Deepti" uniqKey="Goel D" first="Deepti" last="Goel">Deepti Goel</name><name sortKey="Mancuso, Peter" sort="Mancuso, Peter" uniqKey="Mancuso P" first="Peter" last="Mancuso">Peter Mancuso</name><name sortKey="O Rien, Edmund" sort="O Rien, Edmund" uniqKey="O Rien E" first="Edmund" last="O Rien">Edmund O Rien</name><name sortKey="Prano, Joseph" sort="Prano, Joseph" uniqKey="Prano J" first="Joseph" last="Prano">Joseph Prano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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